Category Research papers

Autoimmune and inflammatory diseases following COVID-19

Emerging reports show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection precedes the appearance of various autoimmune and autoinflammatory diseases, including paediatric inflammatory multisystemic syndrome (PIMS) or multisystem inflammatory syndrome in children (MIS-C), thus adding to the growing mystery… Continue Reading →

Pangolins are not the intermediate hosts for the novel coronavirus

The outbreak of a novel corona Virus Disease 2019 (COVID-19) in the city of Wuhan, China has resulted in more than 1.7 million laboratory confirmed cases all over the world. Recent studies showed that SARS-CoV-2 was likely originated from bats, but its intermediate hosts are still largely unknown. In this study, we assembled the complete genome of a coronavirus identified in 3 sick Malayan pangolins. The molecular and phylogenetic analyses showed that this pangolin coronavirus (pangolin-CoV-2020) is genetically related to the SARS-CoV-2 as well as a group of bat coronaviruses but do not support the SARS-CoV-2 emerged directly from the pangolin-CoV-2020. Our study suggests that pangolins are natural hosts of Betacoronaviruses. Large surveillance of coronaviruses in pangolins could improve our understanding of the spectrum of coronaviruses in pangolins. In addition to conservation of wildlife, minimizing the exposures of humans to wildlife will be important to reduce the spillover risks of coronaviruses from wild animals to humans.

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008421

The outbreak of a novel corona Virus Disease 2019 (COVID-19) in the city of Wuhan, China has resulted in more than 1.7 million laboratory confirmed cases all over the world. Recent studies showed that SARS-CoV-2 was likely originated from bats,… Continue Reading →

Some Indian novel coronavirus (SARS-Cov-2) isolates form a new sub-group

New genome sequences of the novel coronavirus, combined with fresh analysis, show a new viral sub-type in India, in addition to already existing sub-types.
https://www.biorxiv.org/content/10.1101/2020.05.31.126136v1

New genome sequences of the novel coronavirus, combined with fresh analysis, show a new viral sub-type in India, in addition to already existing sub-types.https://www.biorxiv.org/content/10.1101/2020.05.31.126136v1

Epidemic parameters for COVID-19 in several regions of India

Bayesian analysis of publicly available time series of cases and fatalities in different geographical regions of India during April 2020 is reported. It is found that the initial apparent rapid growth in infections could be partly due to confounding factors… Continue Reading →

The origins of SARS-CoV-2

The first cases of COVID-19, the disease caused by the SARS-CoV-2 virus, were reported in December, 2019 in the city of Wuhan, in the Hubei province of China. It is therefore reasonable to assume that the disease originated in or around Wuhan.
41 cases of COVID-19 were reported to local health authorities in Wuhan, during December 16, 2019 to January, 2020. The clinical features of these patients were reported in this study in the journal Lancet, in February, 2020:

Broad-spectrum antiviral agent against novel coronavirus (SARS-CoV-2)

Broad-spectrum antivirals are desirable, particularly in the context of emerging zoonotic infections for which specific interventions do not yet exist. Sheahan et al. tested the potential of a ribonucleoside analog previously shown to be active against other RNA viruses such as influenza and Ebola virus to combat coronaviruses. This drug was effective in cell lines and primary human airway epithelial cultures against multiple coronaviruses including SARS-CoV-2. Mouse models of SARS and MERS demonstrated that early treatment reduced viral replication and damage to the lungs. Mechanistically, this drug is incorporated into the viral RNA, inducing mutations and eventually leading to error catastrophe in the virus. In this manner, inducing catastrophe could help avoid catastrophe by stemming the next pandemic.

Human antibody against SARS-CoV-2 infection identified

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

https://www.nature.com/articles/s41467-020-16256-y

Airborne transmission of SARS-CoV-2: The world should face the reality

Manuscript link:

https://www.sciencedirect.com/science/article/pii/S016041202031254X?via%3Dihub

A research paper discussing the possibility of airborne transmission of SARS-Cov2.

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