Emerging reports show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection precedes the appearance of various autoimmune and autoinflammatory diseases, including paediatric inflammatory multisystemic syndrome (PIMS) or multisystem inflammatory syndrome in children (MIS-C), thus adding to the growing mystery… Continue Reading →
The outbreak of a novel corona Virus Disease 2019 (COVID-19) in the city of Wuhan, China has resulted in more than 1.7 million laboratory confirmed cases all over the world. Recent studies showed that SARS-CoV-2 was likely originated from bats, but its intermediate hosts are still largely unknown. In this study, we assembled the complete genome of a coronavirus identified in 3 sick Malayan pangolins. The molecular and phylogenetic analyses showed that this pangolin coronavirus (pangolin-CoV-2020) is genetically related to the SARS-CoV-2 as well as a group of bat coronaviruses but do not support the SARS-CoV-2 emerged directly from the pangolin-CoV-2020. Our study suggests that pangolins are natural hosts of Betacoronaviruses. Large surveillance of coronaviruses in pangolins could improve our understanding of the spectrum of coronaviruses in pangolins. In addition to conservation of wildlife, minimizing the exposures of humans to wildlife will be important to reduce the spillover risks of coronaviruses from wild animals to humans.
The outbreak of a novel corona Virus Disease 2019 (COVID-19) in the city of Wuhan, China has resulted in more than 1.7 million laboratory confirmed cases all over the world. Recent studies showed that SARS-CoV-2 was likely originated from bats,… Continue Reading →
New genome sequences of the novel coronavirus, combined with fresh analysis, show a new viral sub-type in India, in addition to already existing sub-types.
New genome sequences of the novel coronavirus, combined with fresh analysis, show a new viral sub-type in India, in addition to already existing sub-types.https://www.biorxiv.org/content/10.1101/2020.05.31.126136v1
Bayesian analysis of publicly available time series of cases and fatalities in different geographical regions of India during April 2020 is reported. It is found that the initial apparent rapid growth in infections could be partly due to confounding factors… Continue Reading →
The first cases of COVID-19, the disease caused by the SARS-CoV-2 virus, were reported in December, 2019 in the city of Wuhan, in the Hubei province of China. It is therefore reasonable to assume that the disease originated in or around Wuhan.
41 cases of COVID-19 were reported to local health authorities in Wuhan, during December 16, 2019 to January, 2020. The clinical features of these patients were reported in this study in the journal Lancet, in February, 2020:
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.
A research paper discussing the possibility of airborne transmission of SARS-Cov2.