Antibodies against the Spike protein could range from neutralizing ones that will stop the virus in its tracks all the way to others that would cause antibody-dependent enhancement and make the viral infection even worse (see below), and we don’t know how the mutational landscape might alter the activity of any given monoclonal candidate. A new preprint on spike muations (from researchers at Los Alamos, Duke, and Sheffield) has gotten a great deal of attention in the last couple of days, and I think that a detailed look at it would be useful to help explain these issues.
https://blogs.sciencemag.org/pipeline/archives/2020/05/07/mutations-in-the-coronavirus-spike-protein
https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1.full.pdf
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