Category ISRC discussions

Since its inception, the ISRC group has been having intense discussions on many topics. We give pointers to a few of the external resources, links, analysis etc that have emerged from these discussions.

Resource about ongoing COVID-19 trials worldwide and in India

Consolidated resource about ongoing COVID-19

https://clinicaltrials.gov/ct2/results/map/click?map.x=636&map.y=492&cond=COVID-19&map=SS&mapw=1259

Consolidated resource about ongoing COVID-19 https://clinicaltrials.gov/ct2/results/map/click?map.x=636&map.y=492&cond=COVID-19&map=SS&mapw=1259

Mutations in the Coronavirus Spike Protein

Antibodies against the Spike protein could range from neutralizing ones that will stop the virus in its tracks all the way to others that would cause antibody-dependent enhancement and make the viral infection even worse (see below), and we don’t know how the mutational landscape might alter the activity of any given monoclonal candidate. A new preprint on spike muations (from researchers at Los Alamos, Duke, and Sheffield) has gotten a great deal of attention in the last couple of days, and I think that a detailed look at it would be useful to help explain these issues.

https://blogs.sciencemag.org/pipeline/archives/2020/05/07/mutations-in-the-coronavirus-spike-protein

https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1.full.pdf

Antibodies against the Spike protein could range from neutralizing ones that will stop the virus in its tracks all the way to others that would cause antibody-dependent enhancement and make the viral infection even worse (see below), and we don’t… Continue Reading →

Reducing transmission of novel coronavirus (SARS-CoV-2) – Masks and Aerosols

Masks and testing are necessary to combat asymptomatic spread in aerosols and droplets

https://science.sciencemag.org/content/early/2020/05/27/science.abc6197

Masks and testing are necessary to combat asymptomatic spread in aerosols and droplets https://science.sciencemag.org/content/early/2020/05/27/science.abc6197

Visualization of week-wise COVID-19 symptoms

Recent Updates: A much larger scale study of over 26 lakh participants who self reported symptoms on a smartphone-based app.  https://www.nature.com/articles/s41591-020-0916-2#Tab1 Real-time tracking of self-reported symptoms to predict potential COVID-19 We report that loss of smell and taste is a potential… Continue Reading →

Some Indian novel coronavirus (SARS-Cov-2) isolates form a new sub-group

New genome sequences of the novel coronavirus, combined with fresh analysis, show a new viral sub-type in India, in addition to already existing sub-types.
https://www.biorxiv.org/content/10.1101/2020.05.31.126136v1

New genome sequences of the novel coronavirus, combined with fresh analysis, show a new viral sub-type in India, in addition to already existing sub-types.https://www.biorxiv.org/content/10.1101/2020.05.31.126136v1

COVID-19 symptom tracker (worldwide)

To upload most recent infographic, along with this link:

https://docs.google.com/document/d/1KmLkOArlJem-PArnBMbSp-S_E3OozD47UzvRG4qM5Yk/edit

To upload most recent infographic, along with this link: https://docs.google.com/document/d/1KmLkOArlJem-PArnBMbSp-S_E3OozD47UzvRG4qM5Yk/edit

Summary of recent progress on understanding COVID-19

Summarizes recent progress in understanding the epidemiological, virological, and clinical characteristics of COVID-19 and discuss potential targets with existing drugs for the treatment of this emerging zoonotic disease.

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008536

Summarizes recent progress in understanding the epidemiological, virological, and clinical characteristics of COVID-19 and discuss potential targets with existing drugs for the treatment of this emerging zoonotic disease. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008536

Simulations showing possible futures with COVID-19

Live simulations that help you visualize multiple COVID-19 futures!

https://ncase.me/covid-19/

Live simulations that help you visualize multiple COVID-19 futures! https://ncase.me/covid-19/

Infographic on contact tracing

An infographic on how well designed digital contact tracing apps can help us fight COVID-19!

https://ncase.me/contact-tracing/

An infographic on how well designed digital contact tracing apps can help us fight COVID-19! https://ncase.me/contact-tracing/

Epidemic parameters for COVID-19 in several regions of India

Bayesian analysis of publicly available time series of cases and fatalities in different geographical regions of India during April 2020 is reported. It is found that the initial apparent rapid growth in infections could be partly due to confounding factors… Continue Reading →

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